California’s Leading Health Data Utility
Delivering real-time data that powers healthcare transformation

As the largest nonprofit health data network in California, Manifest MedEx (MX) is an integral part of the state’s health data infrastructure, combining and delivering crucial health information for more than 38 million Californians across every county throughout the state.


CA Healthcare organizations




health plans

38 Million

Individual Records

MX is taking bold steps toward health transformation, working with partners on the local and state level to address health equity challenges and support population health management initiatives. As a mission-driven, nonprofit QHIO, we are committed to supporting all Data Exchange Framework (DxF) participants — regardless of their location, technical capabilities, or resources —to achieve CalAIM and DxF goals by improving efficiency and patient outcomes, and enabling whole person care.

With the California ADT Network, MX is creating a digital health safety net by enabling hospitals, health systems, skilled nursing facilities, and QHIOs participating in the DxF to securely send and receive basic ADT notifications for free to improve patient care and help meet DxF data sharing requirements.

Health Plans

Participate alongside California’s leading health plans in using data to care for millions of members. With the MX network, health plans can improve efficiency and member experience with faster, more informed care coordination, identify and resolve care gaps, manage population health, and streamline HEDIS reporting with NCQA-validated data.


Join more than 130 participating California hospitals on the network today. With immediate access to real-time notifications, longitudinal health records, and valuable insights on usage and leakage patterns, MX helps hospitals reduce readmissions, improve care coordination, efficiently manage networks, and easily meet new CMS ADT requirements.


Succeed in value-based care with a powerful data connection across the state. Longitudinal and real-time MX data delivered straight to more than 2,100 ambulatory providers helps clinicians save time, succeed in risk-based contracts, and provide coordinated, person-centered care to patients.

Counties and Public Health

Achieve whole person care and community health goals with MX’s real-time alerts, longitudinal patient records including SDOH data, and comprehensive analytics that can be used to identify and target high risk populations so that those most vulnerable get the care they need, when they need it.

Why Manifest MedEx?

We are a California network with national connectivity, exchanging health data with national and regional networks, so that participants can share data across a broad healthcare ecosystem. And we go beyond just the secure delivery of reliable and accurate health data to ensure that the information is ready to bring value to your clinicians and patients.

Explore the suite of MX solutions available to every participant, which includes direct data feeds, NCQA Validated data streams, and access to our applications.

MX Notify

Receive real-time hospital admit, discharge, and transfer (ADT) information on your patients when they need help the most. Through flexible integrations with more than 70+ EMR and other technology systems, MX Notify conveniently brings one of the most powerful health data tools to your teams.


Explore MX Notify

MX Access

View detailed longitudinal health records for your patients, including recent encounters, allergies, medications, lab results, vaccination status, COVID status, and others — all from the largest health data network in California.


Explore MX Access

MX Analyze

Utilize powerful public health and population risk management tools that turn MX data into actionable insights. Easy-to-use analytics help you to understand more about your patient population, identify your highest risk segments to target for interventions, and succeed in risk-based contracts.


Explore MX Analyze

News and Case Studies

Manifest MedEx Designated a Qualified Health Information Organization (QHIO) in the California Health and Human Services Data Exchange Framework

California’s largest nonprofit health data network qualified by state to support health organizations in meeting data sharing requirements by January 2024 deadline. Emeryville, Calif. – (BUSINESS WIRE) – Manifest MedEx (MX), California’s largest nonprofit health information organization (HIO), announced today that its application as a Qualified Health Information Organization (QHIO) in the California Health and…

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Congratulations to the Eight Recipients of the CDII Educational Initiative Grants Under the DxF Grant Program!

America’s Physician Groups California Academy of Family Physicians   Purchaser Business Group on Health California Quality Collaborative   California Association of Health Care Facilities   California Association of Area Agencies on Aging   California Association of Health Information Exchanges Connecting for Better Health  California Medical Association  California Primary Care Association  County Health Executives Association of…

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Optimizing and Streamlining HEDIS® Reporting With Health Information Exchange Data

How an innovative health plan saves time and improves quality scores with data from Manifest MedEx As part of its quality improvement efforts, Health Plan of San Joaquin uses HEDIS® to measure performance and gauge quality and effectiveness of care provided to their members. Developed and maintained by NCQA, the performance measures in HEDIS® are related to…

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Building Public Health Data Infrastructure Is Key to Precision Public Health

Leveraging health information exchanges gives public health the functionality needed to modernize and flex to the ever-changing landscape of disease and need around us We are at an important crossroads for public health in this country. The COVID-19 pandemic has highlighted that our woefully underfunded public health infrastructures are in desperate need for modernization, starting…

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Choice Medical Group Leverages Longitudinal Patient Records from Manifest MedEx to Succeed Under Full-Risk Value-Based Care Model

Founded more than 30 years ago, Choice Medical Group (CMG) is a primary care and multi-specialty medical group and independent practice association (IPA) serving the High Desert community in San Bernardino County. The group is comprised of more than 200 physicians, four inclusive facilities, and 12 local urgent care facilities. Operating on an employed model…

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Keep Your Eyes on These Four Health Data Advancements in 2023

California is at a moment of opportunity with ambitious goals to improve health equity and achieve “A Healthy California for All” — goals that will require robust health data infrastructure and will fundamentally change the way healthcare is delivered in our state. This kind of infrastructure transformation, while desperately needed and the right thing to…

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“Overview: Understanding the Data Exchange Framework and Data Sharing Agreement Requirements under AB133” Webinar Recap

Most healthcare entities will be required under AB133 legislation to share health data with each other by 2024 through the CalHHS Data Exchange Framework (DxF). The DxF comprises a single Data Sharing Agreement (DSA) and a common set of Policies and Procedures (P&Ps) that will govern the exchange of health and social services information among…

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Incentivizing Data Sharing Among Health Plans, Hospitals, and Providers To Improve Quality

Health plans can gain efficiencies and improve quality by connecting to health information networks and incentivizing hospital and provider participation as part of pay-for-performance programs. Health plans, hospitals, and providers are increasingly recognizing that sharing claims and clinical data can help them coordinate care, reduce costs, manage population health, improve patient experience and outcomes, and…

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Industry Voices—How One Community Health Plan Increased COVID Vaccinations by 40% Using HIE Data

The development of safe, effective, lifesaving vaccines is complex scientific work. But the job does not end there. As we’ve seen with COVID-19—and now with monkeypox, polio, measles and other serious public health issues—there is also a science to the process of connecting with the community and getting the vaccines actually administered. Aggregating health data…

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“Achieving Equity, Coordination, and Care – It All Starts With Data” Webinar Recap

COVID-19 has highlighted the deep disparities in health and health access plaguing our communities. It has also underscored that data gaps perpetuate inequities and block progress. Improving health equity requires quicker insights and better data. To address these issues, and succeed in California’s bold Medicaid transformation plans, Manifest MedEx hosted a discussion that emphasized the…

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Op-Ed: Health Equity for Patients Starts With Digital Equity for Providers

California has made progress building health data networks across the state for years now — data systems that securely deliver information on your medications, health history, and hospitalizations in real time between your different healthcare providers (imagine never having to fill out that clipboard before your medical appointment again!). While those technology systems are significantly…

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Central Neighborhood Health Foundation Uses Manifest MedEx To Improve Post Discharge Follow-Up and Care for Underserved Communities

Central Neighborhood Health Foundation (CNHF) is a network of Medicare-certified, federally qualified health centers (FQHCs) that provide care in medically underserved areas (MUAs) in Los Angeles County and the Inland Empire. The mission of CNHF is to minimize disparities in healthcare access and outcomes by providing superior-quality, patient-centered healthcare through an integrated delivery system for…

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Our Network

Join more than 1800+ California healthcare organizations, including over 130 hospitals, 16 health plans, and results from LabCorp, Quest, and Radnet.

Ready to learn more about Manifest MedEx?

We are California’s largest nonprofit health data network and a designated qualified health information organization (QHIO) in the CalHHS Data Exchange Framework — actively monitoring, delivering and integrating patient data in or near real-time across a diverse network of data contributors — to provide healthcare organizations with the information they need to improve care, enhance health, and lower costs.